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Allergic asthma in patients with common variable immunodeficiency.
- Source :
-
Allergy [Allergy] 2010 Apr; Vol. 65 (4), pp. 510-5. Date of Electronic Publication: 2009 Oct 15. - Publication Year :
- 2010
-
Abstract
- Background: Many patients with common variable immunodeficiency (CVID) have a clinical history suggestive of allergic respiratory disease. However, in such individuals, the prevalence of asthma and the role of atopy have not been well established. The objective of this study was to evaluate pulmonary function and identify asthma in patients with CVID. We also investigated the role of IgE as a trigger of asthma in these patients.<br />Methods: Sixty-two patients diagnosed with CVID underwent spirometry, as well as skin prick testing and in vitro determination of serum-specific IgE levels for aeroallergens, together with bronchial provocation with histamine and allergen.<br />Results: The most common alteration identified through spirometry was obstructive lung disease, which was observed in 29 (47.5%) of the 62 patients evaluated. Eighteen (29.0%) of the 62 patients had a clinical history suggestive of allergic asthma. By the end of the study, asthma had been diagnosed in nine (14.5%) patients and atopy had been identified in six (9.7%). In addition, allergic asthma had been diagnosed in four patients (6.5% of the sample as a whole; 22.2% of the 18 patients with a clinical history suggestive of the diagnosis).<br />Conclusion: In this study, CVID patients testing negative for specific IgE antibodies and suspected of having allergic asthma presented a positive response to bronchial provocation tests with allergens. To our knowledge, this is the first such study. When CVID patients with a history suggestive of allergic asthma test negative on traditional tests, additional tests designed to identify allergic asthma might be conducted.
- Subjects :
- Adolescent
Adult
Aged
Asthma epidemiology
Common Variable Immunodeficiency epidemiology
Female
Humans
Immunoglobulin E blood
Male
Middle Aged
Prevalence
Respiratory Function Tests
Skin Tests
Young Adult
Asthma complications
Asthma immunology
Common Variable Immunodeficiency complications
Common Variable Immunodeficiency immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1398-9995
- Volume :
- 65
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 19839975
- Full Text :
- https://doi.org/10.1111/j.1398-9995.2009.02211.x