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Familial selective IgA deficiency with circulating anti-IgA antibodies: a distinct group of patients?
- Source :
-
Clinical immunology and immunopathology [Clin Immunol Immunopathol] 1991 Jan; Vol. 58 (1), pp. 92-101. - Publication Year :
- 1991
-
Abstract
- Two families were investigated in which the mothers had selective IgA deficiency and circulating class-specific anti-IgA antibodies. Both gave birth to two children who were found to be IgA deficient. Three of these children developed anti-IgA antibodies before puberty. In vitro immunoglobulin production studies performed in the children of both families revealed an IgA B cell defect combined with IgA-specific excessive T suppressor function in all four. The mechanisms by which transplacental passage of maternal anti-IgA antibodies could have interfered with the developing IgA system in the offspring are discussed.
Details
- Language :
- English
- ISSN :
- 0090-1229
- Volume :
- 58
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical immunology and immunopathology
- Publication Type :
- Academic Journal
- Accession number :
- 1983972
- Full Text :
- https://doi.org/10.1016/0090-1229(91)90151-y