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Is antigen specificity of autoreactive T cells the key to islet entry?

Authors :
Penaranda C
Bluestone JA
Source :
Immunity [Immunity] 2009 Oct 16; Vol. 31 (4), pp. 534-6.
Publication Year :
2009

Abstract

It has been widely hypothesized that pancreatic islet infiltrates include both islet-antigen-specific and nonspecific T cells. In this issue of Immunity, Lennon et al. (2009) demonstrate that islet-antigen specificity is required for accumulation in the islets.

Subjects

Subjects :
Animals
Autoantigens immunology
Islets of Langerhans metabolism
Mice
Mice, Inbred NOD
Mice, Transgenic
Receptors, Antigen, T-Cell metabolism
T-Lymphocyte Subsets metabolism
T-Lymphocyte Subsets transplantation
Autoimmunity immunology
Diabetes Mellitus, Type 1 immunology
Islets of Langerhans immunology
Receptors, Antigen, T-Cell immunology
T-Lymphocyte Subsets immunology

Details

Language :
English
ISSN :
1097-4180
Volume :
31
Issue :
4
Database :
MEDLINE
Journal :
Immunity
Publication Type :
Academic Journal
Accession number :
19833083
Full Text :
https://doi.org/10.1016/j.immuni.2009.09.006
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