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The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 2010 Jun; Vol. 72 (6), pp. 752-7. Date of Electronic Publication: 2009 Oct 15. - Publication Year :
- 2010
-
Abstract
- Objective: Parathyroid hormone increases the differentiation of osteoblast precursors through canonical wingless (Wnt) signalling, resulting in an osteoanabolic effect. We aimed to evaluate serum levels of the Wnt-inhibitor Dickkopf-1 (Dkk-1) in postmenopausal women with established osteoporosis and their changes with teriparatide (TPTD - human recombinant PTH 1-34).<br />Design and Patients: A total of 31 postmenopausal Caucasian women with established osteoporosis (mean age 66.3 +/- 1.4 years) received daily injections of 20 microg TPTD for 18 months. Follow-up was continued for another 6 months after treatment discontinuation (total duration of treatment 24 months).<br />Measurements: Serum samples for total calcium (Ca), intact PTH (iPTH), bone-specific alkaline phosphatase, C-terminal cross-linking telopeptide of type 1 collagen (CTx) and Dkk-1 were obtained at baseline, and at 6, 18 and 24 months after TPTD initiation. Lumbar spine bone mineral density (BMD) was measured before and after 18 months of TPTD treatment. A total of 16 age- and gender-matched healthy controls were also analysed at baseline.<br />Results: Serum Dkk-1 levels at baseline were significantly higher in osteoporotic women compared with that in controls (P < 0.002). Dkk-1 increased significantly during TPTD administration (P < 0.044) and decreased to baseline 6 months after TPTD discontinuation. Dkk-1 change was positively correlated to Ca (r = 0.530, P = 0.004) and negatively correlated to iPTH change (r = -0.398, P = 0.040). There was no correlation between Dkk-1 and BMD changes.<br />Conclusions: Our data suggest that Dkk-1 levels are increased in women with postmenopausal osteoporosis. TPTD therapy results in further increase of Dkk-1 that may be compensative to TPTD-induced enhanced Wnt signalling.
- Subjects :
- Aged
Bone Density drug effects
Bone Density Conservation Agents administration & dosage
Bone Density Conservation Agents pharmacology
Calcium blood
Female
Follow-Up Studies
Humans
Lumbar Vertebrae drug effects
Middle Aged
Parathyroid Hormone blood
Teriparatide administration & dosage
Intercellular Signaling Peptides and Proteins blood
Osteoporosis, Postmenopausal blood
Osteoporosis, Postmenopausal drug therapy
Teriparatide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2265
- Volume :
- 72
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 19832854
- Full Text :
- https://doi.org/10.1111/j.1365-2265.2009.03728.x