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Main roads to melanoma.
- Source :
-
Journal of translational medicine [J Transl Med] 2009 Oct 14; Vol. 7, pp. 86. Date of Electronic Publication: 2009 Oct 14. - Publication Year :
- 2009
-
Abstract
- The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness, clinical behavior, and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and/or clinical outcome. Actually, some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have been described. Genes and molecules which control either cell proliferation, apoptosis, or cell senescence have been implicated. Here we provided an overview of the main molecular changes underlying the pathogenesis of melanoma. All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes. Progression from normal melanocytes to malignant metastatic cells in melanoma patients is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.
- Subjects :
- Animals
Cyclin-Dependent Kinase 4 genetics
Cyclin-Dependent Kinase 4 metabolism
Cyclin-Dependent Kinase Inhibitor p16 genetics
Cyclin-Dependent Kinase Inhibitor p16 metabolism
Disease Progression
Humans
Isoenzymes genetics
Isoenzymes metabolism
Microphthalmia-Associated Transcription Factor genetics
Microphthalmia-Associated Transcription Factor metabolism
Neoplasm Metastasis
Nitric Oxide Synthase genetics
Nitric Oxide Synthase metabolism
PTEN Phosphohydrolase genetics
PTEN Phosphohydrolase metabolism
Proto-Oncogene Proteins B-raf genetics
Proto-Oncogene Proteins B-raf metabolism
Proto-Oncogene Proteins c-akt genetics
Proto-Oncogene Proteins c-akt metabolism
Signal Transduction physiology
Cell Transformation, Neoplastic pathology
Melanoma etiology
Melanoma pathology
Melanoma physiopathology
Skin Neoplasms etiology
Skin Neoplasms pathology
Skin Neoplasms physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1479-5876
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of translational medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19828018
- Full Text :
- https://doi.org/10.1186/1479-5876-7-86