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Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils.
Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils.
- Source :
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Neuroscience letters [Neurosci Lett] 2009 Dec 25; Vol. 467 (2), pp. 135-8. Date of Electronic Publication: 2009 Oct 12. - Publication Year :
- 2009
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Abstract
- The effects on distortion product otoacoustic emissions (DPOAEs) during the late phase of ischemia/reperfusion injury in the cochlea were studied. Ischemia/reperfusion injury was induced in a gerbil model by occluding both vertebral arteries for 15min. Hearing was assessed by recording compound action potentials (CAPs) before, during, and 7 days after ischemia. The histological changes in the hair cells were evaluated in specimens stained with rhodamine-phalloidin and Hoechst 33342. The average increase in CAP threshold 7 days after ischemia was 16.3+/-8.0dB at 8kHz. In contrast, interruption of the blood supply to the cochlea decreased the DPOAE amplitudes to the noise floor; this usually recovered to the same level as that seen under pre-ischemic conditions 7 days after ischemia. Histologically, the mean respective losses of inner and outer hair cells (IHCs and OHCs, respectively) of the inner ear were 26.5% and 3.3% in the basal turn, respectively. These results indicate that in gerbils OHCs are tolerant to ischemia/reperfusion injury pathologically and physiologically because DPOAE is closely related to the active process of OHCs and is a useful test to examine OHC function.
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 467
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 19822188
- Full Text :
- https://doi.org/10.1016/j.neulet.2009.10.023