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Fatigue and quality of life after risk-reducing salpingo-oophorectomy in women at increased risk for hereditary breast-ovarian cancer.
- Source :
-
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2009 Aug; Vol. 19 (6), pp. 1029-36. - Publication Year :
- 2009
-
Abstract
- Background: Risk-reducing salpingo-oophorectomy (RRSO) is the safest intervention for prevention of ovarian cancer in women at increased risk for hereditary breast-ovarian cancer. Little is known about other effects of RRSO. The objective of this study was to investigate quality of life (QoL) and fatigue in a sample of women who had RRSO for increased cancer risk and to compare the findings with those of age-matched controls from the general population (NORM).<br />Materials and Methods: In a cross-sectional follow-up mailed questionnaire design, 301 (67%) of 450 invited Norwegian women with RRSO attended. The questionnaire contained measures of QoL, fatigue, anxiety/depression, and body image, and questions about demography, lifestyle, and morbidity. The findings were compared with those of the NORM.<br />Results: For RRSO women, mean age at survey was 53.7 years (SD, 9.2), mean age at RRSO was 48.4 years (SD 8.4), and median follow-up time was 5.0 years (range, 1-15 years). No clinically significant differences were observed between RRSO and NORM for any of the QoL or fatigue dimensions. In subgroup analyses of the RRSO group, no clinically significant differences in QoL and fatigue were observed between those who had surgery before or after age 50 years, or between BRCA1/2 carriers and women with unknown mutation statuses. Women who had cancer (32%), however, showed clinically significant lower levels of QoL and more fatigue than women without cancer.<br />Conclusions: Women who had RRSO showed similar levels of QoL and fatigue as NORM. Women who had cancer before RRSO had lower levels of QoL and more fatigue.
- Subjects :
- Adult
Breast Neoplasms complications
Breast Neoplasms genetics
Case-Control Studies
Cross-Sectional Studies
Fatigue etiology
Female
Genes, BRCA1
Genes, BRCA2
Humans
Middle Aged
Mutation physiology
Norway epidemiology
Ovarian Neoplasms complications
Ovarian Neoplasms genetics
Ovariectomy rehabilitation
Ovariectomy statistics & numerical data
Postoperative Complications epidemiology
Risk Factors
Risk Reduction Behavior
Salpingostomy rehabilitation
Salpingostomy statistics & numerical data
Surveys and Questionnaires
Breast Neoplasms surgery
Fatigue epidemiology
Genetic Predisposition to Disease
Ovarian Neoplasms surgery
Ovariectomy adverse effects
Quality of Life
Salpingostomy adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1438
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
- Publication Type :
- Academic Journal
- Accession number :
- 19820364
- Full Text :
- https://doi.org/10.1111/IGC.0b013e3181a83cd5