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Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2010 Feb 10; Vol. 627 (1-3), pp. 8-15. Date of Electronic Publication: 2009 Oct 07. - Publication Year :
- 2010
-
Abstract
- Demethoxycurcumin (DMC) is one of the main active compounds of curcuminoids found in turmeric powder, which is used as a spice in Asian cooking and traditional medicine. Recent studies reveal that DMC has several biological activities including anti-inflammation and anti-cancer activities. However, the molecular mechanism by which DMC has anti-metastasis activity in breast cancer cells remains poorly understood. Here, we report for the first time that DMC inhibited adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. For cancer cell migration and invasion, extracellular matrix (ECM) degradation processes are required. MDA-MB-231 cells treated with DMC had decreased levels of ECM degradation-associated proteins including matrix metalloproteinase-9 (MMP-9), membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase plasminogen activator (uPA) and uPA receptor (uPAR), while the level of uPA inhibitor (PAI-1) was up-regulated. Moreover, DMC also reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and chemokine receptor 4, (CXCR4), which is involved in modulation of the tumor metastasis process. We also found that DMC treatment inhibited the DNA binding activity of nuclear factor-kappa B (NF-kappaB), which is known to mediate the expression of MMPs, uPA, uPAR, ICAM-1, and CXCR4. These findings strongly suggest that the mechanism of DMC-mediated anti-invasive activity involves modulation of the expression of invasion-associated proteins, possibly by targeting NF-kappaB in MDA-MB-231 cells.<br /> (Copyright (c) 2009 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Breast Neoplasms genetics
Breast Neoplasms metabolism
Cell Adhesion drug effects
Cell Line, Tumor
Curcumin pharmacology
DNA metabolism
Diarylheptanoids
Extracellular Matrix drug effects
Extracellular Matrix metabolism
Gene Expression Regulation, Neoplastic drug effects
Humans
Intercellular Adhesion Molecule-1 metabolism
NF-kappa B metabolism
Neoplasm Invasiveness prevention & control
Neoplasm Metastasis
Receptors, CXCR4 metabolism
Breast Neoplasms pathology
Cell Movement drug effects
Curcumin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 627
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19818349
- Full Text :
- https://doi.org/10.1016/j.ejphar.2009.09.052