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Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients.
- Source :
-
European journal of internal medicine [Eur J Intern Med] 2009 Nov; Vol. 20 (7), pp. 712-7. Date of Electronic Publication: 2009 Sep 06. - Publication Year :
- 2009
-
Abstract
- Background: Although many studies have shown that the metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) both are associated with chronic inflammatory state and are risk factors for coronary artery disease (CAD), it is still unclear which condition is a more important contributor to the increased production of inflammatory chemokines. The purpose of this study was to assess monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) levels and their association with insulin resistance and adiponectin concentrations in CAD patients, who were categorized as having T2DM, MS, or neither.<br />Methods: CAD male patients were categorized into three groups: 24 non-obese patients with T2DM (D), 24 obese patients with MS (M) and 24 patients without T2DM or MS (W). 20 healthy subjects were selected as controls (C). Insulin resistance was assessed by the HOMA-IR method, but serum MCP-1, IL-8, and adiponectin levels were measured by xMAP technology.<br />Results: Serum levels of MCP-1 and IL-8 in D and M groups were increased in comparison with W and C groups (p<0.001, p<0.01), but the increase in the M group was significantly higher than that in the D group (p<0.05, p<0,001), besides MCP-1 and IL-8 concentrations were correlated with HOMA-IR indexes (r=0.52; r=0.49, p<0.0001) and adiponectin levels (r=-0.59, p<0.0001). The M group demonstrated a diminution in the adiponectin level (p<0.01) and pronounced increase of HOMA-IR in comparison with the other three groups (p<0.01).<br />Conclusion: Obese CAD patients with MS have a more pronounced increase of MCP-1, IL-8 and HOMA-IR and more decreased adiponectin levels than non-obese CAD patients without MS.
- Subjects :
- Adiponectin blood
Adiponectin deficiency
Adult
Aged
Biomarkers blood
Coronary Artery Disease blood
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 epidemiology
Diabetes Mellitus, Type 2 immunology
Humans
Insulin Resistance immunology
Male
Metabolic Syndrome blood
Metabolic Syndrome epidemiology
Metabolic Syndrome immunology
Middle Aged
Obesity blood
Obesity epidemiology
Obesity immunology
Risk Factors
Chemokine CCL2 blood
Coronary Artery Disease epidemiology
Coronary Artery Disease immunology
Interleukin-8 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0828
- Volume :
- 20
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19818293
- Full Text :
- https://doi.org/10.1016/j.ejim.2009.08.004