Back to Search
Start Over
Tomographic left ventricular volumetric emptying analysis by real-time 3-dimensional echocardiography: influence of left ventricular dysfunction with and without electrical dyssynchrony.
- Source :
-
Circulation. Cardiovascular imaging [Circ Cardiovasc Imaging] 2008 Jul; Vol. 1 (1), pp. 41-9. - Publication Year :
- 2008
-
Abstract
- Background: The sequence of left ventricular (LV) systolic emptying is not completely understood. Using real-time 3-dimensional echocardiography, we investigated this sequence and LV synchronicity in physiological and pathological conditions.<br />Methods and Results: The study population consisted of 116 healthy volunteers, 20 top-level athletes, 35 patients with LV dysfunction, and 84 patients with LV dysfunction and left bundle-branch block (LBBB). We subdivided the LV into 16 volumetric segments for regional analysis and into apical, middle, and basal regions to calculate the mean of end-systolic times and the time to minimum systolic volume of each region. In healthy volunteers and in top-level athletes, the emptying systolic times increased smoothly from apex to base. These differences determined an apex-to-base time gradient in the LV emptying sequence. In patients with LV dysfunction and without LBBB, this gradient was maintained with a relatively higher LV dyssynchrony. However, in patients with LV dysfunction and LBBB, there was no clear sequence in LV emptying volumes, and this group had the highest LV dyssynchrony.<br />Conclusions: Real-time 3-dimensional echocardiography tomographic slicing of the LV enables accurate analysis of LV emptying in physiological conditions and in conditions of LV dysfunction with and without electrical dyssynchrony. Progressive dilation of LV produces deterioration in LV synchronicity. However, it is the presence of LV dysfunction in combination with LBBB that determines the loss of the apex-to-base time gradient in LV emptying.
- Subjects :
- Adolescent
Adult
Aged
Bundle-Branch Block physiopathology
Case-Control Studies
Female
Heart Failure physiopathology
Humans
Hypertrophy, Left Ventricular diagnostic imaging
Hypertrophy, Left Ventricular physiopathology
Image Interpretation, Computer-Assisted
Italy
Male
Middle Aged
Observer Variation
Predictive Value of Tests
Reproducibility of Results
Switzerland
Time Factors
Ventricular Dysfunction, Left physiopathology
Young Adult
Bundle-Branch Block diagnostic imaging
Echocardiography, Three-Dimensional
Heart Failure diagnostic imaging
Myocardial Contraction
Sports
Stroke Volume
Ventricular Dysfunction, Left diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0080
- Volume :
- 1
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 19808513
- Full Text :
- https://doi.org/10.1161/CIRCIMAGING.107.763110