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New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii.
- Source :
-
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2009 Oct; Vol. 57 (10), pp. 1119-22. - Publication Year :
- 2009
-
Abstract
- Two new friedelane-type triterpenes named 12alpha-hydroxyfriedelane-3,15-dione and 3beta-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii Hutch. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some gram-positive and gram-negative bacteria, and they appeared to be modestly active.
- Subjects :
- Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Disk Diffusion Antimicrobial Tests
Euphorbiaceae chemistry
Magnetic Resonance Spectroscopy
Molecular Conformation
Plant Stems chemistry
Triterpenes isolation & purification
Triterpenes pharmacology
Anti-Bacterial Agents chemistry
Triterpenes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5223
- Volume :
- 57
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Chemical & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 19801870
- Full Text :
- https://doi.org/10.1248/cpb.57.1119