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Cutting Edge: Tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2009 Oct 15; Vol. 183 (8), pp. 4848-52. - Publication Year :
- 2009
-
Abstract
- We previously reported that naive, tumor-specific CD8(+) (TcR-I) T cells transferred into prostate tumor-bearing mice traffic to the prostate where they become tolerized. We now report that TcR-I cells suppress the proliferation of naive T cells. This suppression is mediated at least in part by secreted factors, and the suppressive activity can be blocked by Abs directed against TGF-beta. We further report that TcR-I cells must infiltrate the prostate to acquire suppressive activity. Delivery of tumor-specific CD4(+) T cells prevents the conversion of TcR-I cells into suppressor cells. Taken together, our findings may have critical implications for sustaining T cell responsiveness during immunotherapy, as the development of suppressor cells in the tumor microenvironment may eliminate the potency of T cells primed in the periphery or delivered during adoptive immunotherapy.
- Subjects :
- Animals
Antibodies immunology
CD8-Positive T-Lymphocytes transplantation
Immune Tolerance
Immunotherapy, Adoptive
Lymphocytes, Tumor-Infiltrating transplantation
Male
Mice
Mice, Transgenic
Prostatic Neoplasms therapy
T-Lymphocytes, Regulatory metabolism
Transforming Growth Factor beta metabolism
CD8-Positive T-Lymphocytes immunology
Lymphocytes, Tumor-Infiltrating immunology
Prostatic Neoplasms immunology
T-Lymphocytes, Regulatory immunology
Transforming Growth Factor beta immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 183
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 19801511
- Full Text :
- https://doi.org/10.4049/jimmunol.0900848