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The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers.

Authors :
Martínez MF
Martín XE
Alcelay LG
Flores JC
Valiente JM
Juanbeltz BI
Beldarraín MA
López JM
Gonzalez-Fernández MC
Salazar AM
Gandarias RB
Borda SI
Marqués NO
Amillano MB
Zabaleta MC
de Pancorbo MM
Source :
BMC neuroscience [BMC Neurosci] 2009 Sep 30; Vol. 10, pp. 125. Date of Electronic Publication: 2009 Sep 30.
Publication Year :
2009

Abstract

Background: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE).A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups.The DNA Bank of the University of the Basque Country (UPV-EHU) (Spain) determined COMT Val158 Met and APOE genotypes using real time polymerase chain reaction (rtPCR) and polymerase chain reaction (PCR), and restriction fragment length polymorphism (RFLPs), respectively. Multinomial logistic regression models were used to determine the risk of AD and MCI.<br />Results: Neither COMT alleles nor genotypes were independent risk factors for AD or MCI. The high activity genotypes (GG and AG) showed a synergistic effect with APOE epsilon4 allele, increasing the risk of AD (OR = 5.96, 95%CI 2.74-12.94, p < 0.001 and OR = 6.71, 95%CI 3.36-13.41, p < 0.001 respectively). In AD patients this effect was greater in women.In MCI patients such as synergistic effect was only found between AG and APOE epsilon4 allele (OR = 3.21 95%CI 1.56-6.63, p = 0.02) and was greater in men (OR = 5.88 95%CI 1.69-20.42, p < 0.01).<br />Conclusion: COMT (Val158 Met) polymorphism is not an independent risk factor for AD or MCI, but shows a synergistic effect with APOE epsilon4 allele that proves greater in women with AD.

Details

Language :
English
ISSN :
1471-2202
Volume :
10
Database :
MEDLINE
Journal :
BMC neuroscience
Publication Type :
Academic Journal
Accession number :
19793392
Full Text :
https://doi.org/10.1186/1471-2202-10-125