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Mucosal remodeling in long-standing ulcerative colitis with colorectal neoplasia: significant alterations of NCAM+ or alpha-SMA+ subepithelial myofibroblasts and interstitial cells.
- Source :
-
Pathology international [Pathol Int] 2009 Oct; Vol. 59 (10), pp. 701-11. - Publication Year :
- 2009
-
Abstract
- Evidence has been provided in ulcerative colitis (UC) that early genomic instability of both epithelial and stromal cells is important for colorectal tumorigenesis, as well as remodeling and morphological alterations of mucosal crypts. To clarify roles of stromal cells in tumor development in UC, the present study focused on heterogeneous phenotypes of subepithelial myofibroblasts and interstitial cells, in association with mucosal remodeling. To clarify the relationship of alterations to tumorigenesis, mucosa of resected rectae from patients with UC (n= 49) and sporadic cancer (n= 10) were analyzed on immunohistochemistry and also on immunoelectron microscopy. Heterogeneous phenotypes of neural cell adhesion molecule (NCAM)+ and/or alpha-smooth muscle actin (alpha-SMA)+ subepithelial myofibroblasts and interstitial cells were demonstrated, corresponding to colonic stellate cells. Decrease of NCAM+ subepithelial myofibroblasts and interstitial cells, and increase of alpha-SMA+ interstitial cells were significant in UC with neoplasia as compared to without neoplasia. alpha-SMA+ muscularis mucosae was significantly more thickened in tumor cases. Deposits of Masson's trichrome+ and type III and I collagen in the muscularis mucosae and lamina propria appeared to increase in relation to the numbers of alpha-SMA+ interstitial cells. Mucosal remodeling with alterations of NCAM+ or alpha-SMA+ subepithelial and interstitial cells may play a critical role in UC-associated tumorigenesis.
- Subjects :
- Adenocarcinoma pathology
Adenocarcinoma surgery
Adolescent
Adult
Aged
Biomarkers, Tumor metabolism
Colitis, Ulcerative pathology
Colitis, Ulcerative surgery
Colorectal Neoplasms pathology
Colorectal Neoplasms surgery
Female
Fibroblasts metabolism
Fibroblasts ultrastructure
Humans
Immunoenzyme Techniques
Intestinal Mucosa surgery
Male
Microscopy, Immunoelectron
Middle Aged
Muscle, Smooth metabolism
Muscle, Smooth pathology
Stromal Cells metabolism
Stromal Cells ultrastructure
Young Adult
Actins metabolism
Adenocarcinoma metabolism
Colitis, Ulcerative metabolism
Colorectal Neoplasms metabolism
Intestinal Mucosa metabolism
Neural Cell Adhesion Molecules metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1827
- Volume :
- 59
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pathology international
- Publication Type :
- Academic Journal
- Accession number :
- 19788615
- Full Text :
- https://doi.org/10.1111/j.1440-1827.2009.02432.x