Back to Search
Start Over
Expanded TCR Vbeta subsets of CD8(+) T-cells in late-onset myasthenia gravis: novel parallels with thymoma patients.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2009 Nov 30; Vol. 216 (1-2), pp. 85-91. Date of Electronic Publication: 2009 Sep 24. - Publication Year :
- 2009
-
Abstract
- Little is known about pathogenesis -- and especially about involvement of CD8(+) T-cells -- in late-onset myasthenia gravis (LOMG). Remarkably, outstanding CD8(+) TCRVbeta-subset expansions were found in 64% and 72% of recent onset LOMG or thymoma-associated MG (vs. 16% with early-onset MG (p<0.0002); 21% in older controls (p<0.001)). In LOMG, ~25% of the expanded cells initially showed a naïve CD62L(+hi)/CD45RA(+) recent thymic emigrant (RTE)-like phenotype. These expansions associated significantly with IgG antibodies against cytomegalovirus (p<0.036), IL-12 and/ or IFN-alpha2 (p<0.03). The CD8(+) TCRVbeta expansions were stable over 5years, but RTE markers declined.
- Subjects :
- Adult
Age of Onset
Aged
Autoantibodies blood
CD8-Positive T-Lymphocytes metabolism
Cytomegalovirus immunology
Diagnosis, Differential
Female
Humans
Immunophenotyping
Interferon-gamma immunology
Interleukin-12 immunology
L-Selectin metabolism
Leukocyte Common Antigens metabolism
Lymphocyte Activation immunology
Male
Middle Aged
Myasthenia Gravis metabolism
Myasthenia Gravis physiopathology
Recombinant Proteins
Thymoma metabolism
Thymoma physiopathology
CD8-Positive T-Lymphocytes immunology
Myasthenia Gravis immunology
Receptors, Antigen, T-Cell, alpha-beta physiology
Thymoma immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 216
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 19781791
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2009.08.018