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A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects.
- Source :
-
The British journal of nutrition [Br J Nutr] 2010 Feb; Vol. 103 (3), pp. 422-8. Date of Electronic Publication: 2009 Sep 28. - Publication Year :
- 2010
-
Abstract
- Type 2 diabetes is associated with a higher cardiovascular risk and there has been a growing interest in using dietary intervention to improve lipid profile and glucose control. The present work aims at analysing the effects of the enrichment of a normal diet with beta-glucan (3.5 g/d) in free-living type 2 diabetic subjects for 2 months, using a palatable soup. This trial was a parallel, placebo-controlled, double-blinded randomised study performed in fifty-three type 2 diabetic subjects. During a 3-week run-in period, subjects daily consumed a ready meal control soup (without beta-glucan). For the following 8 weeks, subjects were randomly assigned to consume daily either a control soup or a beta-glucan soup. Changes in lipid profile (total cholesterol (TC), HDL- and LDL-cholesterol (HDLc and LDLc), apo B and TAG) and in glucose control (HbA1c and fasting glucose) were measured. There was no significant alteration in lipid profile in the two groups (TC, HDLc, LDLc and apo B). TAG decreased significantly in the beta-glucan group compared with the control group ( - 0.12 (SD 0.38) v. 0.12 (SD 0.44) mmol/l, P = 0.03). HbA1c and fasting glucose were not reduced in any group. A single daily ingestion of 3.5 g beta-glucan, as required by official dietary recommendations, for 8 weeks did not change the lipid profile and HbA1c in type 2 diabetic subjects. To improve the metabolic profile of type 2 diabetic subjects in the long term, the quantity, the food vectors and the tolerability of beta-glucan products may be re-evaluated.
- Subjects :
- Aged
Avena
Blood Glucose drug effects
Blood Glucose metabolism
Body Weight
C-Reactive Protein drug effects
C-Reactive Protein metabolism
Cardiovascular Diseases prevention & control
Cholesterol, HDL blood
Cholesterol, HDL drug effects
Cholesterol, LDL blood
Cholesterol, LDL drug effects
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Diabetic Angiopathies prevention & control
Diet, Diabetic
Double-Blind Method
Glycated Hemoglobin drug effects
Glycated Hemoglobin metabolism
Humans
Middle Aged
Placebos
Risk Factors
Surveys and Questionnaires
beta-Glucans therapeutic use
Cardiovascular Diseases epidemiology
Diabetes Mellitus, Type 2 physiopathology
Diabetic Angiopathies epidemiology
Lipids blood
beta-Glucans pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 103
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 19781120
- Full Text :
- https://doi.org/10.1017/S0007114509991875