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Cytomegalovirus disease during severe drug eruptions: report of 2 cases and retrospective study of 18 patients with drug-induced hypersensitivity syndrome.
- Source :
-
Archives of dermatology [Arch Dermatol] 2009 Sep; Vol. 145 (9), pp. 1030-6. - Publication Year :
- 2009
-
Abstract
- Background: Overt cytomegalovirus (CMV) disease is a serious viral infection that usually occurs in immunocompromised patients but rarely in immunocompetent patients. Cutaneous lesions, albeit rare, occur as late systemic manifestations of CMV infections and are usually fatal.<br />Observations: We describe 2 patients with drug-induced hypersensitivity syndrome (one end of a spectrum of severe drug eruptions) who subsequently developed cutaneous CMV ulcers at unusual sites, such as the trunk; this occurrence was immediately followed by gastrointestinal manifestations, which were fatal in 1 patient. To identify factors predictive of CMV disease, we retrospectively investigated the prevalence of CMV reactivation during drug-induced hypersensitivity syndrome in 18 patients. In this analysis, patients were divided into 2 groups depending on the positivity of CMV DNA in the blood.<br />Conclusions: Older and male patients with antecedent high human herpesvirus 6 DNA loads are at risk for CMV disease irrespective of corticosteroid administration. A rapid reduction in white blood cell numbers is also predictive of the onset of CMV disease.
- Subjects :
- Adult
Aged
Aged, 80 and over
Cytomegalovirus genetics
Cytomegalovirus Infections diagnosis
Cytomegalovirus Infections virology
DNA, Viral analysis
Diagnosis, Differential
Drug Eruptions diagnosis
Endoscopy, Gastrointestinal
Fatal Outcome
Follow-Up Studies
Humans
Male
Middle Aged
Polymerase Chain Reaction
Retrospective Studies
Severity of Illness Index
Young Adult
Cytomegalovirus isolation & purification
Cytomegalovirus Infections complications
Drug Eruptions complications
Subjects
Details
- Language :
- English
- ISSN :
- 1538-3652
- Volume :
- 145
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Archives of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 19770444
- Full Text :
- https://doi.org/10.1001/archdermatol.2009.195