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[Urticaria pigmentosa: a current approach].
- Source :
-
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) [Rev Alerg Mex] 2009 Jul-Aug; Vol. 56 (4), pp. 124-35. - Publication Year :
- 2009
-
Abstract
- The term urticaria pigmentosa (UP) denotes a heterogeneous group of disorders characterized by abnormal growth and accumulation of mast cells (MC) in the skin. Symptoms result from MC chemical mediator's release, pathologic infiltration of neoplastic MC in tissues or both. Multiple molecular, genetic and chromosomal defects seem contribute to an autonomous growth, but somatic c-kit D816V mutation is more frequently found, especially in systemic disease. The aim of this paper is to provide a current overview for a better understanding of the symptoms associated with this disease, to describe its classification, recent advances in its pathophysiology and its treatment.
- Subjects :
- Adrenal Cortex Hormones therapeutic use
Adult
Age of Onset
Child
Child, Preschool
Comorbidity
Diagnosis, Differential
Histamine Antagonists therapeutic use
Humans
Hypersensitivity epidemiology
Infant
Infant, Newborn
Mast Cells metabolism
Mast Cells pathology
Mastocytosis classification
Mutation, Missense
Point Mutation
Proto-Oncogene Proteins c-kit genetics
Proto-Oncogene Proteins c-kit physiology
Stem Cell Factor physiology
Urticaria Pigmentosa diagnosis
Urticaria Pigmentosa drug therapy
Urticaria Pigmentosa epidemiology
Urticaria Pigmentosa genetics
Urticaria Pigmentosa pathology
Urticaria Pigmentosa physiopathology
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0002-5151
- Volume :
- 56
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
- Publication Type :
- Academic Journal
- Accession number :
- 19768974