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Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Authors :
Yeager M
Chatterjee N
Ciampa J
Jacobs KB
Gonzalez-Bosquet J
Hayes RB
Kraft P
Wacholder S
Orr N
Berndt S
Yu K
Hutchinson A
Wang Z
Amundadottir L
Feigelson HS
Thun MJ
Diver WR
Albanes D
Virtamo J
Weinstein S
Schumacher FR
Cancel-Tassin G
Cussenot O
Valeri A
Andriole GL
Crawford ED
Haiman CA
Henderson B
Kolonel L
Le Marchand L
Siddiq A
Riboli E
Key TJ
Kaaks R
Isaacs W
Isaacs S
Wiley KE
Gronberg H
Wiklund F
Stattin P
Xu J
Zheng SL
Sun J
Vatten LJ
Hveem K
Kumle M
Tucker M
Gerhard DS
Hoover RN
Fraumeni JF Jr
Hunter DJ
Thomas G
Chanock SJ
Source :
Nature genetics [Nat Genet] 2009 Oct; Vol. 41 (10), pp. 1055-7. Date of Electronic Publication: 2009 Sep 20.
Publication Year :
2009

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

Details

Language :
English
ISSN :
1546-1718
Volume :
41
Issue :
10
Database :
MEDLINE
Journal :
Nature genetics
Publication Type :
Academic Journal
Accession number :
19767755
Full Text :
https://doi.org/10.1038/ng.444