Multiple loci on 8q24 associated with prostate cancer susceptibility.

Authors :: Al Olama AA
Kote-Jarai Z
Giles GG
Guy M
Morrison J
Severi G
Leongamornlert DA
Tymrakiewicz M
Jhavar S
Saunders E
Hopper JL
Southey MC
Muir KR
English DR
Dearnaley DP
Ardern-Jones AT
Hall AL
O'Brien LT
Wilkinson RA
Sawyer E
Lophatananon A
Horwich A
Huddart RA
Khoo VS
Parker CC
Woodhouse CJ
Thompson A
Christmas T
Ogden C
Cooper C
Donovan JL
Hamdy FC
Neal DE
Eeles RA
Easton DF
Source :: Nature genetics [Nat Genet] 2009 Oct; Vol. 41 (10), pp. 1058-60. Date of Electronic Publication: 2009 Sep 20.
Publication Year :: 2009
Abstract: Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.