Back to Search
Start Over
Human hepatocyte transplantation: state of the art.
- Source :
-
Journal of internal medicine [J Intern Med] 2009 Oct; Vol. 266 (4), pp. 339-57. - Publication Year :
- 2009
-
Abstract
- Hepatocyte transplantation is making its transition from bench to bedside for liver-based metabolic disorders and acute liver failure. Over eighty patients have now been transplanted world wide and the safety of the procedure together with medium-term success has been established. A major limiting factor in the field is the availability of good quality cells as hepatocytes are derived from grafts that are deemed unsuitable for transplantation. Alternative sources of cell, including stem cells may provide a sustainable equivalent to primary hepatocytes. There is also a need to develop techniques that will improve the engraftment, survival and function of transplanted hepatocytes. Such developments may allow hepatocyte transplantation to become an accepted and practical alternative to liver transplantation in the near future.
- Subjects :
- Animals
Cell Transplantation methods
Graft Survival immunology
Hepatocytes immunology
Humans
Liver Diseases complications
Liver Failure, Acute immunology
Liver Failure, Acute surgery
Metabolic Diseases etiology
Models, Animal
Hepatocytes transplantation
Liver Diseases surgery
Metabolic Diseases surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2796
- Volume :
- 266
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19765179
- Full Text :
- https://doi.org/10.1111/j.1365-2796.2009.02152.x