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Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas.
- Source :
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Pathology, research and practice [Pathol Res Pract] 2009; Vol. 205 (12), pp. 854-7. Date of Electronic Publication: 2009 Sep 16. - Publication Year :
- 2009
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Abstract
- Angiogenesis is a multistep process that depends on the balance of proangiogenic factors and inhibitors as well as on interactions with the extracellular matrix. We examined the immunohistochemical expression of the defining angiogenic agents, vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9), and the antiangiogenic agent thrombospondin-1 (TSP-1) in 131 patients with urothelial carcinoma and correlated their expression levels with clinicopathological parameters. VEGF and MMP-9 expression was higher in high-grade tumors than in low-grade tumors (p=0.000 and p=0.001, respectively), whereas the reverse was true for TSP-1 (p=0.000). VEGF and MMP-9 expression was higher in deeper tumors compared to superficial tumors and in invasive tumors compared to non-invasive tumors (p=0.001 and p=0.001, respectively), while TSP-1 was lower (p=0.000). We could differentiate 22 of 41 muscle-invasive (T2) cases as superficial (T2a; n=7) or deep (T2b; n=15), but no difference was found between them regarding VEGF, MMP-9, or TSP-1 expression (p=0.783, p=0.289, and p=0.783, respectively). There was a positive correlation between VEGF and MMP-9 expression (p=0.008, r=0.23) but a negative correlation between MMP-9 and TSP-1 expression (p=0.014, r=-0.21). Increased VEGF and MMP-9 expression as well as decreased TSP-1 expression may play considerable roles in the invasion and differentiation of urothelial carcinoma.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma blood supply
Carcinoma enzymology
Carcinoma pathology
Cell Differentiation
Female
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Urinary Bladder Neoplasms blood supply
Urinary Bladder Neoplasms enzymology
Urinary Bladder Neoplasms pathology
Urothelium blood supply
Urothelium enzymology
Urothelium pathology
Young Adult
Carcinoma chemistry
Matrix Metalloproteinase 9 analysis
Thrombospondin 1 analysis
Urinary Bladder Neoplasms chemistry
Urothelium chemistry
Vascular Endothelial Growth Factor A analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 205
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 19762163
- Full Text :
- https://doi.org/10.1016/j.prp.2009.07.015