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Limited role of fetal blood sampling in prediction of outcome in intrauterine growth retardation.
- Source :
-
Lancet (London, England) [Lancet] 1990 Sep 29; Vol. 336 (8718), pp. 768-72. - Publication Year :
- 1990
-
Abstract
- Fetal acid-base status was evaluated on 66 blood samples taken for rapid karyotyping from 58 growth-retarded fetuses. Before blood sampling, doppler blood flow studies of the umbilical artery showed end-diastolic frequencies to be absent in 32 fetuses (group 1) and present in 26 (group 2). Fetuses with chromosomal (n = 4) or structural (n = 8) abnormalities were excluded from subsequent analysis. Gestational age at blood sampling (27.8 [95% CI 26.5-29.1] vs 32.2 [30.4-34.1] weeks) and time from sampling to delivery (median 2 (range 0-35] vs 14 [0-77] days) were significantly lower in group 1 than group 2. There were no perinatal deaths in group 2 whereas mortality in group 1 was 65.4%. There were significant differences between the groups at blood sampling in pH, pO2, pCO2, base equivalents, and nucleated-red-cell count, but within group 1 these measurements were similar in surviving fetuses and those who died perinatally. Since acid-base determination does not predict perinatal outcome in growth-retarded fetuses, fetal blood sampling has a limited role in monitoring fetal wellbeing.
- Subjects :
- Adaptation, Physiological
Adolescent
Adult
Blood Flow Velocity
Blood Gas Analysis
Evaluation Studies as Topic
Female
Fetal Growth Retardation diagnosis
Fetal Growth Retardation genetics
Fetal Growth Retardation mortality
Fetal Monitoring methods
Gestational Age
Humans
Predictive Value of Tests
Pregnancy
Pregnancy Outcome genetics
Prognosis
Time Factors
Ultrasonography
Acid-Base Imbalance blood
Fetal Blood analysis
Fetal Growth Retardation blood
Umbilical Arteries
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 336
- Issue :
- 8718
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 1976146
- Full Text :
- https://doi.org/10.1016/0140-6736(90)93239-l