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Impact of neoadjuvant chemotherapy with FOLFOX/FOLFIRI on disease-free and overall survival of patients with colorectal metastases.
- Source :
-
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract [J Gastrointest Surg] 2009 Nov; Vol. 13 (11), pp. 2003-9; discussion 2009-10. Date of Electronic Publication: 2009 Sep 16. - Publication Year :
- 2009
-
Abstract
- Study Aims: To determine if neoadjuvant FOLFOX/FOLFIRI is associated with improved disease-free survival (DFS) or overall survival (OS) in patients with colorectal metastases (CRM) to the liver.<br />Methods: Ninety-nine patients (from 457 eligible) with CRM that underwent hepatic resection during 2000 to 2005 were included. Group 1 (n = 44) patients received neoadjuvant FOLFOX/FOLFIRI, and Group 2 (n = 55) did not receive neoadjuvant therapy.<br />Results: There were 58% men. The median age for Group 1 was 58 and Group 2, 64 (p = 0.03). OS for Group 1 at 1, 3, and 5 years was 93%, 62%, and 51%, respectively, with a median OS of 5.8 years. In Group 2 survival at 1l, 3, and 5 years was 90%, 63%, and 45%, respectively, with a median OS of 3.7 years (HR 1.06, p = 0.87). The DFS for Group 1 at 1, 3, and 5 years was 51%, 20%, and 20%, with a median DFS of 1.1 years and Group 2 at 1, 3, and 5 years was 58%, 32%, and 32% (median DFS-1.2 years; HR = 1.24, p = 0.45).<br />Conclusions: Neoadjuvant FOLFOX/FOLFIRI was employed more frequently in younger patients with CRM; however, neoadjuvant chemotherapy for CRM was not significantly associated with an increase in OS or DFS, despite additional adjuvant therapy.
- Subjects :
- Camptothecin analogs & derivatives
Camptothecin therapeutic use
Chemotherapy, Adjuvant
Colorectal Neoplasms drug therapy
Colorectal Neoplasms surgery
Disease-Free Survival
Female
Fluorouracil therapeutic use
Hepatectomy
Humans
Leucovorin therapeutic use
Male
Middle Aged
Neoadjuvant Therapy
Organoplatinum Compounds therapeutic use
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Colorectal Neoplasms mortality
Colorectal Neoplasms pathology
Liver Neoplasms mortality
Liver Neoplasms secondary
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4626
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
- Publication Type :
- Academic Journal
- Accession number :
- 19760306
- Full Text :
- https://doi.org/10.1007/s11605-009-1007-3