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RGS16 is a marker for prognosis in colorectal cancer.
- Source :
-
Annals of surgical oncology [Ann Surg Oncol] 2009 Dec; Vol. 16 (12), pp. 3507-14. Date of Electronic Publication: 2009 Sep 04. - Publication Year :
- 2009
-
Abstract
- Background: The RGS family, comprising 22 homologues of proteins, plays a role in cellular proliferation, differentiation, membrane trafficking, and embryonic development through the involvement of the mitogen-activated protein kinase signaling pathway.<br />Methods: In order to demonstrate the importance of RGS16 expression for the prediction of prognosis of colorectal cancer (CRC), we analyzed RGS16 gene expression in 22 human gastrointestinal cell lines and 124 paired cases of CRC and noncancerous regions.<br />Results: RGS16 was expressed in 17 human gastrointestinal cancer cell lines examined in this study. RGS16 expression was higher in colorectal cancer tissue than in corresponding normal tissue (P < 0.001) in messenger RNA (mRNA) and protein levels. Patients in the RGS16 high-expression group showed a poorer overall survival rate than those in the low-expression group (P < 0.001), indicating that high RGS16 expression was an independent prognostic factor.<br />Conclusion: The present study suggests that RGS16 is useful as a predictive marker for patient prognosis of CRC.
- Subjects :
- Aged
Colon metabolism
Colon pathology
Colorectal Neoplasms genetics
Colorectal Neoplasms pathology
Female
Follow-Up Studies
Gastrointestinal Neoplasms genetics
Gastrointestinal Neoplasms pathology
Humans
Immunoenzyme Techniques
Male
Neoplasm Proteins genetics
Neoplasm Staging
Prognosis
RNA, Messenger genetics
RNA, Messenger metabolism
RNA-Binding Proteins genetics
Rectum metabolism
Rectum pathology
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Tumor Cells, Cultured
Biomarkers, Tumor metabolism
Colorectal Neoplasms metabolism
Gastrointestinal Neoplasms metabolism
Neoplasm Proteins metabolism
RNA-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1534-4681
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Annals of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19760045
- Full Text :
- https://doi.org/10.1245/s10434-009-0690-3