Back to Search
Start Over
Stanford V program for locally extensive and advanced Hodgkin lymphoma: the Memorial Sloan-Kettering Cancer Center experience.
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2010 Mar; Vol. 21 (3), pp. 574-581. Date of Electronic Publication: 2009 Sep 16. - Publication Year :
- 2010
-
Abstract
- Background: The Stanford group has reported excellent results with the Stanford V regimen for patients with bulky and/or advanced Hodgkin lymphoma (HL). However, Gobbi reported markedly inferior failure-free survival (FFS) comparing Stanford V to other regimens but included major deviations from the original program. We retrospectively examined whether treatment at our institution carefully following Stanford V guidelines would confirm the original Stanford outcome data.<br />Patients and Methods: From June 1995 to May 2002, 126 patients with either locally extensive or advanced HL were treated with the 12-week Stanford V chemotherapy program followed by 36-Gy involved-field radiotherapy to sites initially > or =5 cm and/or to macroscopic splenic disease. Overall, 26% had stage IV disease and 20% had international prognostic score (IPS) > or =4. Overall survival (OS), disease-specific survival, progression-free survival (PFS), FFS, and freedom from second relapse (FF2R) were determined.<br />Results: The 5- and 7-year OS were 90% and 88%, respectively. The 5-year FFS was 78%. IPS > or =4 was a significant independent predictor of worse OS and PFS. The FF2R was 64% at 3 years.<br />Conclusion: Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL.
- Subjects :
- Adolescent
Adult
Aged
Combined Modality Therapy
Disease-Free Survival
Female
Hodgkin Disease drug therapy
Hodgkin Disease radiotherapy
Humans
Male
Middle Aged
Neoplasm Recurrence, Local drug therapy
Neoplasm Recurrence, Local radiotherapy
Neoplasm Staging
Retrospective Studies
Salvage Therapy
Survival Rate
Treatment Outcome
Young Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Hodgkin Disease therapy
Neoplasm Recurrence, Local therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1569-8041
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19759185
- Full Text :
- https://doi.org/10.1093/annonc/mdp337