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Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26.
- Source :
-
Archives of ophthalmology (Chicago, Ill. : 1960) [Arch Ophthalmol] 2009 Sep; Vol. 127 (9), pp. 1168-74. - Publication Year :
- 2009
-
Abstract
- Objective: To characterize progression of geographic atrophy (GA) associated with age-related macular degeneration in AREDS as measured by digitized fundus photographs.<br />Methods: Fundus photographs from 181 of 4757 AREDS participants with a GA area of at least 0.5 disc areas at baseline or from participants who developed bilateral GA during follow-up were scanned, digitized, and evaluated longitudinally. Geographic atrophy area was determined using planimetry. Rates of progression from noncentral to central GA and of vision loss following development of central GA included the entire AREDS cohort.<br />Results: Median initial lesion size was 4.3 mm(2). Average change in digital area of GA from baseline was 2.03 mm(2) (standard error of the mean, 0.24 mm(2)) at 1 year, 3.78 mm(2) (0.24 mm(2)) at 2 years, 5.93 mm(2) (0.34 mm(2)) at 3 years, and 1.78 mm(2) (0.086 mm(2)) per year overall. Median time to developing central GA after any GA diagnosis was 2.5 years (95% confidence interval, 2.0-3.0). Average visual acuity decreased by 3.7 letters at first documentation of central GA, and by 22 letters at year 5.<br />Conclusions: Growth of GA area can be reliably measured using standard fundus photographs that are digitized and subsequently graded at a reading center. Development of GA is associated with subsequent further growth of GA, development of central GA, and loss in central vision.
- Subjects :
- Aged
Aged, 80 and over
Antioxidants therapeutic use
Atrophy diagnosis
Atrophy drug therapy
Atrophy physiopathology
Choroidal Neovascularization drug therapy
Choroidal Neovascularization physiopathology
Copper therapeutic use
Disease Progression
Female
Humans
Macular Degeneration drug therapy
Macular Degeneration physiopathology
Male
Middle Aged
Photography
Prospective Studies
Retinal Pigment Epithelium drug effects
Vision Disorders drug therapy
Vision Disorders physiopathology
Visual Acuity physiology
Zinc Oxide therapeutic use
Choroidal Neovascularization diagnosis
Macular Degeneration diagnosis
Retinal Pigment Epithelium pathology
Vision Disorders diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1538-3601
- Volume :
- 127
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Archives of ophthalmology (Chicago, Ill. : 1960)
- Publication Type :
- Academic Journal
- Accession number :
- 19752426
- Full Text :
- https://doi.org/10.1001/archophthalmol.2009.198