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Close relationships, inflammation, and health.
- Source :
-
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2010 Sep; Vol. 35 (1), pp. 33-8. Date of Electronic Publication: 2009 Sep 12. - Publication Year :
- 2010
-
Abstract
- Different aspects of personal relationships including social integration, social support, and social conflict have been related to inflammation. This article summarizes evidence linking the quality and quantity of relationships with gene expression, intracellular signaling mechanisms, and inflammatory biomarkers, and highlights the biological and psychological pathways through which close relationships impact inflammatory responses. Relationship conflict and lower social support can effectively modulate proinflammatory cytokine secretion both directly (via CNS/neural/endocrine/immune biobehavioral pathways), and indirectly, by promoting depression, emotional stress responses, and detrimental health behaviors. Accordingly, thorough assessments of health behaviors and attention to key methodological issues are necessary to identify the contributions of relationships to inflammation, and thus we highlight procedural issues to be considered in the design of studies. Despite some notable methodological challenges, the evidence suggests that learning more about how close relationships influence inflammation will provide important new insights into the ways that relationships impact health.
- Subjects :
- Adiposity physiology
Alcohol Drinking
Animals
Behavior physiology
Chronic Disease
Depression complications
Depression psychology
Female
Humans
Interpersonal Relations
Male
Motor Activity physiology
Smoking
Stress, Psychological complications
Stress, Psychological psychology
Health Status
Inflammation physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7528
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience and biobehavioral reviews
- Publication Type :
- Academic Journal
- Accession number :
- 19751761
- Full Text :
- https://doi.org/10.1016/j.neubiorev.2009.09.003