Back to Search Start Over

Multipyrene tandem probes for detection of C677T polymorphism in MTHFR gene.

Authors :
Kholodar SA
Novopashina DS
Meschaninova MI
Lomzov AA
Venyaminova AG
Source :
Nucleic acids symposium series (2004) [Nucleic Acids Symp Ser (Oxf)] 2009 (53), pp. 143-4.
Publication Year :
2009

Abstract

We designed tandems of oligo(2'-O-methylribonucleotides) conjugates containing two bispyrene (5'-bisPyr and 3'-bisPyr) groups on their junction for detection of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MHTFR). The potential of SNP detection with multipyrene tandems of oligo(2'-O-methylribonucleotides) was demonstrated.

Subjects

Subjects :
Pyrenes chemistry
Fluorescent Dyes chemistry
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Oligonucleotide Probes chemistry
Polymorphism, Single Nucleotide

Details

Language :
English
ISSN :
1746-8272
Issue :
53
Database :
MEDLINE
Journal :
Nucleic acids symposium series (2004)
Publication Type :
Academic Journal
Accession number :
19749301
Full Text :
https://doi.org/10.1093/nass/nrp072
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details