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DCEMRI of spontaneous canine tumors during fractionated radiotherapy: a pharmacokinetic analysis.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2009 Dec; Vol. 93 (3), pp. 618-24. Date of Electronic Publication: 2009 Sep 09. - Publication Year :
- 2009
-
Abstract
- Purpose: To estimate pharmacokinetic parameters from dynamic contrast-enhanced magnetic resonance (DCEMR) images of spontaneous canine tumors taken during the course of fractionated radiotherapy, and to quantify treatment-induced changes in these parameters.<br />Materials and Methods: Six dogs with tumors in the oral or nasal cavity received fractionated conformal radiotherapy with 54 Gy given in 18 fractions. T(1)-weighted DCEMR imaging was performed prior to each treatment fraction. Time-intensity curves in the tumor were extracted voxel-by-voxel, and were fitted to the Brix pharmacokinetic model. The dependence of the pharmacokinetic parameters on the accumulated radiation dose was calculated.<br />Results: The Brix model reproduced the time-intensity curves well. A reduction in the k(ep) parameter with accumulated radiation dose was found for five (three significant) out of six cases, while the results for the A parameter were less consistent. Both pre-treatment k(ep) and the change in k(ep) with accumulated dose correlated significantly with tumor regression.<br />Conclusions: Pharmacokinetic parameters derived from DCEMR images taken during fractionated radiotherapy may predict response to radiotherapy. This may potentially impact on patient stratification and monitoring of treatment response for image-guided treatment strategies.
- Subjects :
- Animals
Dog Diseases diagnosis
Dogs
Dose Fractionation, Radiation
Mouth Neoplasms diagnosis
Mouth Neoplasms radiotherapy
Nose Neoplasms diagnosis
Nose Neoplasms radiotherapy
Radiotherapy Dosage veterinary
Contrast Media pharmacokinetics
Dog Diseases radiotherapy
Gadolinium DTPA pharmacokinetics
Magnetic Resonance Imaging veterinary
Mouth Neoplasms veterinary
Nose Neoplasms veterinary
Radiotherapy, Conformal veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0887
- Volume :
- 93
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 19747746
- Full Text :
- https://doi.org/10.1016/j.radonc.2009.08.012