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Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 15; Vol. 19 (20), pp. 5893-7. Date of Electronic Publication: 2009 Aug 21. - Publication Year :
- 2009
-
Abstract
- A second wave of potential SSRIs with high ease of synthetic accessibility were designed based on the reported selective serotonin re-uptake inhibitor litoxetine and our own previous work in this area. Preparation and subsequent optimisation yielded a range of potent and highly selective SSRIs.
- Subjects :
- Adrenergic Uptake Inhibitors chemistry
Adrenergic Uptake Inhibitors pharmacology
Antidepressive Agents chemical synthesis
Antidepressive Agents pharmacology
Dopamine Uptake Inhibitors chemistry
Dopamine Uptake Inhibitors pharmacology
Drug Design
Serotonin Plasma Membrane Transport Proteins metabolism
Selective Serotonin Reuptake Inhibitors chemical synthesis
Selective Serotonin Reuptake Inhibitors pharmacology
Structure-Activity Relationship
Antidepressive Agents chemistry
Serotonin Plasma Membrane Transport Proteins chemistry
Selective Serotonin Reuptake Inhibitors chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19740658
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.08.066