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Asymmetric intermolecular Pauson-Khand reaction of symmetrically substituted alkynes.
- Source :
-
Organic letters [Org Lett] 2009 Oct 01; Vol. 11 (19), pp. 4346-9. - Publication Year :
- 2009
-
Abstract
- The asymmetric intermolecular Pauson-Khand reaction of symmetric alkynes has been accomplished for the first time. N-Phosphino-p-tolylsulfinamide (PNSO) ligands have been identified as efficient ligands in this process. The chirality of the cobalt S-bonded sulfinyl moiety was found to direct olefin insertion into one of the two possible cobalt-carbon bonds in the alkyne complex. Reaction of symmetric alkynes allows for a simplified experimental protocol since there is no need for separation of diastereomeric complexes.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 11
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 19739661
- Full Text :
- https://doi.org/10.1021/ol901728r