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Targeted delivery of chemotherapeutic agents using improved radiosensitive liquid core microcapsules and assessment of their antitumor effect.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2009 Oct 01; Vol. 75 (2), pp. 455-62. - Publication Year :
- 2009
-
Abstract
- Purpose: Radiation-sensitive microcapsules composed of alginate and hyaluronic acid are being developed. We report the development of improved microcapsules that were prepared using calcium- and yttrium-induced polymerization. We previously reported on the combined antitumor effect of carboplatin-containing microcapsules and radiotherapy.<br />Methods and Materials: We mixed a 0.1% (wt/vol) solution of hyaluronic acid with a 0.2% alginate solution. Carboplatin (l mg) and indocyanine green (12.5 microg) were added to this mixture, and the resultant material was used for capsule preparation. The capsules were prepared by spraying the material into a mixture containing a 4.34% CaCl(2) solution supplemented with 0-0.01% yttrium. These capsules were irradiated with single doses of 0.5, 1.0, 1.5, or 2 Gy (60)Co gamma-rays. Immediately after irradiation, the frequency of microcapsule decomposition was determined using a microparticle-induced X-ray emission camera. The amount of core content released was estimated by particle-induced X-ray emission and colorimetric analysis with 0.25% indocyanine green. The antitumor effect of the combined therapy was determined by monitoring its effects on the diameter of an inoculated Meth A fibrosarcoma.<br />Results: Microcapsules that had been polymerized using a 4.34% CaCl(2) solution supplemented with 5.0 x 10(-3)% (10(-3)% meant or 10%(-3)) yttrium exhibited the maximal decomposition, and the optimal release of core content occurred after 2-Gy irradiation. The microcapsules exhibited a synergistic antitumor effect combined with 2-Gy irradiation and were associated with reduced adverse effects.<br />Conclusion: The results of our study have shown that our liquid core microcapsules can be used in radiotherapy for targeted delivery of chemotherapeutic agents.
- Subjects :
- Alginates administration & dosage
Animals
Antineoplastic Agents adverse effects
Antineoplastic Agents analysis
Antineoplastic Agents chemistry
Calcium analysis
Calcium Chloride analysis
Calcium Chloride chemistry
Capsules adverse effects
Capsules chemical synthesis
Capsules radiation effects
Carboplatin adverse effects
Carboplatin analysis
Carboplatin chemistry
Cobalt Radioisotopes pharmacology
Colorimetry methods
Combined Modality Therapy methods
Drug Compounding methods
Fibrosarcoma chemically induced
Fibrosarcoma chemistry
Fibrosarcoma pathology
Glucuronic Acid administration & dosage
Glucuronic Acid chemistry
Hexuronic Acids administration & dosage
Hexuronic Acids chemistry
Hyaluronic Acid administration & dosage
Mice
Mice, Inbred BALB C
Platinum analysis
Polymers
Time Factors
Yttrium administration & dosage
Yttrium pharmacology
Alginates chemistry
Antineoplastic Agents administration & dosage
Capsules therapeutic use
Carboplatin administration & dosage
Fibrosarcoma drug therapy
Hyaluronic Acid chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-355X
- Volume :
- 75
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 19735868
- Full Text :
- https://doi.org/10.1016/j.ijrobp.2009.02.082