Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers.

Authors :: Mousa SA
Sudha T
Dyskin E
Dier U
Gallati C
Hanko C
Chittur SV
Rebbaa A
Source :: Cancer letters [Cancer Lett] 2010 Mar 28; Vol. 289 (2), pp. 208-16. Date of Electronic Publication: 2009 Sep 04.
Publication Year :: 2010
Abstract: Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in its gene expression. The resistant cells over-expressed various genes associated with tumor aggressiveness, many of which are also expressed in the CD133+ glioma cancer stem cells. These findings suggest that stress-resistant stem cells generated in vitro may be useful for the discovery of novel markers of cancer stem cells.<br /> (Copyright 2009 Elsevier Ireland Ltd. All rights reserved.)

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