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Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.
- Source :
-
Neuroscience letters [Neurosci Lett] 1990 May 18; Vol. 113 (1), pp. 62-5. - Publication Year :
- 1990
-
Abstract
- The effect of acetylcholine (ACh) on intracellular responses to ionophoretic application of N-methyl-D-aspartate (NMDA) was examined in rat hippocampal slice. Recordings were obtained from CA1 neurons under current- and voltage-clamp conditions. Drugs were applied topically by ionophoretic and microdrop techniques. ACh produced an atropine-sensitive potentiation of responses to NMDA. The effect of ACh on NMDA receptor-mediated responses was independent of changes in voltage or potassium conductances caused by ACh. ACh also potentiated responses to L-glutamate but not to kainate or quisqualate. This effect was blocked by DL-2-amino-5-phosphonovalerate (2-APV), an NMDA receptor antagonist. We conclude that ACh, acting on muscarinic receptors, potentiates selectively, the NMDA subclass of L-glutamate receptor.
- Subjects :
- 2-Amino-5-phosphonovalerate pharmacology
Action Potentials drug effects
Animals
Aspartic Acid pharmacology
Glutamates pharmacology
Glutamic Acid
Hippocampus drug effects
In Vitro Techniques
N-Methylaspartate
Neurotransmitter Agents pharmacology
Rats
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter drug effects
Acetylcholine pharmacology
Aspartic Acid analogs & derivatives
Hippocampus physiology
Receptors, Neurotransmitter physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 113
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 1973273
- Full Text :
- https://doi.org/10.1016/0304-3940(90)90495-u