Back to Search Start Over

Acetylcholine potentiates responses to N-methyl-D-aspartate in the rat hippocampus.

Authors :
Markram H
Segal M
Source :
Neuroscience letters [Neurosci Lett] 1990 May 18; Vol. 113 (1), pp. 62-5.
Publication Year :
1990

Abstract

The effect of acetylcholine (ACh) on intracellular responses to ionophoretic application of N-methyl-D-aspartate (NMDA) was examined in rat hippocampal slice. Recordings were obtained from CA1 neurons under current- and voltage-clamp conditions. Drugs were applied topically by ionophoretic and microdrop techniques. ACh produced an atropine-sensitive potentiation of responses to NMDA. The effect of ACh on NMDA receptor-mediated responses was independent of changes in voltage or potassium conductances caused by ACh. ACh also potentiated responses to L-glutamate but not to kainate or quisqualate. This effect was blocked by DL-2-amino-5-phosphonovalerate (2-APV), an NMDA receptor antagonist. We conclude that ACh, acting on muscarinic receptors, potentiates selectively, the NMDA subclass of L-glutamate receptor.

Details

Language :
English
ISSN :
0304-3940
Volume :
113
Issue :
1
Database :
MEDLINE
Journal :
Neuroscience letters
Publication Type :
Academic Journal
Accession number :
1973273
Full Text :
https://doi.org/10.1016/0304-3940(90)90495-u