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The Treatment for Adolescents With Depression Study (TADS): outcomes over 1 year of naturalistic follow-up.
- Source :
-
The American journal of psychiatry [Am J Psychiatry] 2009 Oct; Vol. 166 (10), pp. 1141-9. Date of Electronic Publication: 2009 Sep 01. - Publication Year :
- 2009
-
Abstract
- Objective: The Treatment for Adolescents With Depression Study (TADS) evaluates the effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), and their combination in adolescents with major depressive disorder. The authors report effectiveness outcomes across a 1-year naturalistic follow-up period.<br />Method: The randomized, controlled trial was conducted in 13 academic and community sites in the United States. Stages I, II, and III consisted of 12, 6, and 18 weeks of acute, consolidation, and continuation treatment, respectively. Following discontinuation of TADS treatments at the end of stage III, stage IV consisted of 1 year of naturalistic follow-up. The participants were 327 subjects between the ages of 12 and 17 with a primary DSM-IV diagnosis of major depressive disorder. No TADS treatment was provided during the follow-up period; treatment was available in the community. The primary dependent measures, rated by an independent evaluator blind to treatment status, were the total score on the Children's Depression Rating Scale-Revised and the rate of response, defined as a rating of much or very much improved on the Clinical Global Impressions improvement measure.<br />Results: Sixty-six percent of the eligible subjects participated in at least one stage IV assessment. The benefits seen at the end of active treatment (week 36) persisted during follow-up on all measures of depression and suicidality.<br />Conclusions: In contrast to earlier reports on short-term treatments, in which worsening after treatment is the rule, the longer treatment in the TADS was associated with persistent benefits over 1 year of naturalistic follow-up.
- Subjects :
- Adolescent
Child
Combined Modality Therapy
Depressive Disorder, Major drug therapy
Depressive Disorder, Major psychology
Double-Blind Method
Female
Fluoxetine adverse effects
Follow-Up Studies
Humans
Longitudinal Studies
Male
Selective Serotonin Reuptake Inhibitors adverse effects
Severity of Illness Index
Treatment Outcome
United States
Cognitive Behavioral Therapy
Depressive Disorder, Major therapy
Fluoxetine therapeutic use
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7228
- Volume :
- 166
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 19723787
- Full Text :
- https://doi.org/10.1176/appi.ajp.2009.08111620