Photo-polymeriable chitosan derivative prepared by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA).

Authors :: Ma G
Zhang X
Han J
Song G
Nie J
Source :: International journal of biological macromolecules [Int J Biol Macromol] 2009 Dec 01; Vol. 45 (5), pp. 499-503. Date of Electronic Publication: 2009 Aug 29.
Publication Year :: 2009
Abstract: N-Alkyled photo-polymeriable chitosan derivative (PEGDA-CS) was synthesized by Michael reaction of chitosan and polyethylene glycol diacrylate (PEGDA) under mild reaction conditions. The chemical structure and physical properties of PEGDA-CS were characterized by FT-IR, (1)H NMR, XRD and TG techniques. The degree of substitution (DS) of PEGDA-CS could be calculated from (1)H NMR. PEGDA-CS exhibited good solubility in distilled water. XRD analysis showed that PEGDA-CS was amorphous. TG results demonstrated that thermal stability of the derivate was lower than that of chitosan. Antimicrobial test showed that PEGDA-CS had the antimicrobial activity on Escherichia coli. It could photopolymerize under ultraviolet light with 2959 as initiator.

Subjects :: Anti-Infective Agents pharmacology
Chemistry, Organic methods
Escherichia coli metabolism
Light
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Models, Chemical
Solubility
Spectroscopy, Fourier Transform Infrared methods
Thermogravimetry methods
Ultraviolet Rays
Water chemistry
X-Ray Diffraction
Chitosan chemistry
Polyethylene Glycols chemistry
Polymers chemistry

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