Zn(II)-Catalyzed synthesis of piperidines from propargyl amines and cyclopropanes.

Authors :: Lebold TP
Leduc AB
Kerr MA
Source :: Organic letters [Org Lett] 2009 Aug 20; Vol. 11 (16), pp. 3770-2.
Publication Year :: 2009
Abstract: The reaction of benzyl-protected propargyl amines and 1,1-cyclopropane diesters in the presence of catalytic Zn(NTf(2))(2) allows access to highly functionalized piperidines in excellent yields. The process proceeds via a tandem cyclopropane ring-opening/Conia-ene cyclization.

Subjects :: Catalysis
Combinatorial Chemistry Techniques
Cyclization
Molecular Structure
Pargyline chemistry
Piperidines chemistry
Cyclopropanes chemistry
Pargyline analogs & derivatives
Piperidines chemical synthesis
Propylamines chemistry
Zinc chemistry

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