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Sildenafil treatment of subacute ischemic stroke: a safety study at 25-mg daily for 2 weeks.
- Source :
-
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2009 Sep-Oct; Vol. 18 (5), pp. 381-3. - Publication Year :
- 2009
-
Abstract
- Background: In several animal studies of young and aged rats with ischemic stroke, treatment with sildenafil improved functional outcomes compared with placebo. We conducted a safety study of sildenafil (25 mg daily for 2 weeks) shortly after ischemic stroke onset.<br />Methods: We recruited patients aged 18 to 80 years with ischemic stroke, National Institutes of Health stroke scale (NIHSS) score 2 to 21, between days 2 and 9 after symptom onset. Patients were treated with sildenafil for 2 weeks (25 mg daily). The primary outcome measure was the adverse occurrence of any of the following during the treatment period: stroke worsening, new stroke, myocardial infarction, vision loss, hearing loss, or death from any cause. Secondary outcome measures were NIHSS score, Barthel indices, and modified Rankin score at 90 days.<br />Results: Twelve patients were recruited. Mean age was 57 years, 5 were female, and median NIHSS score at entry was 9.5 (range 2-20). The primary outcome measure occurred in one patient (sudden death). Another patient committed suicide 2 months after study entry (and 6 weeks after treatment with sildenafil had been completed). Among the 10 survivors, at 90 days, median NIHSS score was 2 (range 0-12), median Barthel index was 95 (range 15-100), and median modified Rankin score was 1.5 (range 0-5).<br />Conclusions: Sildenafil (25 mg daily for 2 weeks) appeared to be safe in this group of patients with mild to moderately severe stroke. Further studies of higher doses will be tested.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Blood Pressure drug effects
Blood Pressure physiology
Brain Ischemia prevention & control
Cerebral Arteries drug effects
Cerebral Arteries physiopathology
Cyclic GMP metabolism
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug-Related Side Effects and Adverse Reactions
Female
Humans
Male
Middle Aged
Phosphodiesterase Inhibitors administration & dosage
Phosphodiesterase Inhibitors adverse effects
Piperazines adverse effects
Pulmonary Embolism chemically induced
Purines administration & dosage
Purines adverse effects
Recovery of Function drug effects
Recovery of Function physiology
Sildenafil Citrate
Stroke prevention & control
Sulfones adverse effects
Treatment Outcome
Vasodilator Agents administration & dosage
Vasodilator Agents adverse effects
Venous Thrombosis chemically induced
Young Adult
Brain Ischemia drug therapy
Piperazines administration & dosage
Stroke drug therapy
Sulfones administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8511
- Volume :
- 18
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Publication Type :
- Academic Journal
- Accession number :
- 19717023
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.01.007