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Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation.
- Source :
-
Acta biomaterialia [Acta Biomater] 2010 Mar; Vol. 6 (3), pp. 797-803. Date of Electronic Publication: 2009 Aug 27. - Publication Year :
- 2010
-
Abstract
- Parathyroid hormone-related protein (PTHrP) is an important regulator of bone remodeling. Recent studies show that this protein can induce osteogenic features through its N- and C-terminal domains. Silica-based ordered mesoporous bioceramics with an SBA-15 structure - known to be bioactive and biocompatible - have recently been evaluated for their capacity to uptake and deliver L-tryptophan. This amino acid corresponds to the end position of the 107-111 domain (called osteostatin) of the native C-terminal PTHrP (107-139) fragment, whose true action in bone metabolism is still ill-defined. In the present study, we assessed some effects of the aforementioned biomaterials pressed into disks, loaded or not with osteostatin, in osteoblastic cell cultures. Our data demonstrate that both unmodified and organically modified SBA-15 loaded with this peptide increase cell growth and the expression of several osteoblastic products (alkaline phosphatase, osteocalcin, collagen, osteoprotegerin, receptor activator of nuclear factor-kappaB ligand and vascular endothelial growth factor) in osteoblastic cells. These findings support the notion that osteostatin coating confers osteogenic features to silica-based ordered mesoporous materials, which make them suitable biomaterials for bone repair.<br /> (Copyright 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- 3T3 Cells
Animals
Cell Differentiation drug effects
Cell Proliferation drug effects
Coated Materials, Biocompatible chemistry
Coated Materials, Biocompatible pharmacology
Crystallization methods
Materials Testing
Mice
Osteoblasts drug effects
Osteogenesis drug effects
Osteogenesis physiology
Surface Properties
Tissue Engineering methods
Bone Substitutes chemistry
Bone Substitutes pharmacology
Ceramics chemistry
Osteoblasts cytology
Osteoblasts physiology
Parathyroid Hormone-Related Protein administration & dosage
Parathyroid Hormone-Related Protein chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1878-7568
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta biomaterialia
- Publication Type :
- Academic Journal
- Accession number :
- 19716446
- Full Text :
- https://doi.org/10.1016/j.actbio.2009.08.033