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Olanzapine orally disintegrating tablets (Zyprexa Zydis) rapidly improve excitement components in the acute phase of first-episode schizophrenic patients: an open-label prospective study.
- Source :
-
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2009; Vol. 10 (4 Pt 3), pp. 741-5. - Publication Year :
- 2009
-
Abstract
- An open-label study was performed to investigate the clinical efficacy and tolerability of olanzapine orally disintegrating tablets (Zyprexa Zydis) in ameliorating excitement symptoms in the acute phase of schizophrenia. Fifty-three patients meeting DSM-IV criteria for first-episode schizophrenia and treated with olanzapine monotherapy were evaluated with regard to their clinical improvement, behavioural response to medication, and extrapyramidal side effects using the Positive and Negative Syndrome Scale Excited Component (PANSS-EC), Nursing Assessment of Medication Acceptance (NAMA), and Drug-Induced Extra-Pyramidal Symptoms Scale (DIEPSS), respectively. Scores of PANSS-EC were significantly reduced after 3 days of olanzapine administration. A reduction in NAMA scores was also observed 7 days after administration of olanzapine. The DIEPSS score was unaffected by olanzapine administration. These results suggest that olanzapine orally disintegrating tablets are effective and well-tolerated for treatment excitement in the acute phase of schizophrenic patients. In addition, it is possible that adherence to medications is improved by using olanzapine orally disintegrating tablets.
- Subjects :
- Acute Disease
Administration, Oral
Adolescent
Adult
Aged
Antipsychotic Agents adverse effects
Basal Ganglia Diseases chemically induced
Basal Ganglia Diseases epidemiology
Benzodiazepines adverse effects
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Male
Middle Aged
Mouth
Olanzapine
Patient Compliance statistics & numerical data
Prospective Studies
Psychomotor Agitation diagnosis
Psychomotor Agitation drug therapy
Psychomotor Agitation epidemiology
Schizophrenia diagnosis
Schizophrenia epidemiology
Severity of Illness Index
Solubility
Young Adult
Antipsychotic Agents therapeutic use
Benzodiazepines therapeutic use
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1814-1412
- Volume :
- 10
- Issue :
- 4 Pt 3
- Database :
- MEDLINE
- Journal :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 19707954
- Full Text :
- https://doi.org/10.1080/15622970903166312