Influence of partner's infection status on prevalent human papillomavirus among persons with a new sex partner.

Background: We evaluated the influence of the partner's human papillomavirus (HPV) status and sexual practices on prevalent HPV infection among new couples to study HPV transmission.
Methods: Women attending university or college in Montreal, Canada, and their male partners (N = 263 couples) were enrolled in 2005-2008. HPV typing was done in self-collected vaginal swabs and clinician-collected penis and scrotum swabs. The outcome measures were overall and type-specific HPV prevalence.
Results: HPV was detected in 56% of women and men. Prevalence was higher among persons with infected partners (85%) than in those whose partners were negative (19%). Type-specific detection was substantially higher among women (OR = 55.2, 95% CI: 38.0-80.1) and men (OR = 58.7, 95% CI: 39.8-86.3) if their partner harbored the type under consideration. Prevalence among women and men with 10 or more lifetime partners was 15.4 (95% CI: 5.9-40.2) and 9.5 (95% CI: 4.4-19.8) times higher than among those with 1 partner. Frequent condom use was protective in men, particularly if his partner was HPV-infected (OR = 0.64, 95% CI: 0.50-0.82). This effect was attenuated among women with an infected partner (OR = 0.88, 95% CI: 0.69-1.11).
Conclusions: The current partner's status was the most important risk factor for prevalent HPV infection. Condoms exerted a stronger protective effect among men than among women.