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[Follow-up at 24 months after treatment of overactive bladder with 0.2 % sodium chondroitin sulfate].
- Source :
-
Aktuelle Urologie [Aktuelle Urol] 2009 Nov; Vol. 40 (6), pp. 355-9. Date of Electronic Publication: 2009 Aug 19. - Publication Year :
- 2009
-
Abstract
- Aim: A retrospective study was performed to investigate whether the improvement of symptoms achieved with 0.2 % sodium chondroitin sulfate in treating overactive bladder (OAB) persists after 24 months.<br />Materials and Methods: Two years ago, a total of 82 patients with chronic OAB were randomly assigned to receive either anticholinergic treatment (Tolterodin; group A, n = 41) or 0.2 % sodium chondroitin sulfate (Gepan instill; group B, n = 41). Diagnostic assessment included a gynecological examination and history, urodynamic test-ing, introital ultrasound, and cystoscopy. Duration of treatment was 12 months. The patients underwent repeat follow-up after 24 months and the findings were compared with the results at 12 months.<br />Results: In group A, 15 / 35 (43 %) women reported an improvement of symptoms after 12 months as opposed to only 5 / 35 (14 %) after 24 months. In group B, there was an improvement in 23 / 32 (72 %) at 12 months and in 18 / 32 (56 %) after 24 months (p = 0.001). The subjective results were corroborated by means of urodynamic test-ing, pad counts, voiding frequency and nycturia (voiding diary).<br />Conclusion: Our findings suggest that instillation treatment with 0.2 % sodium chondroitin sulfate results in a more sustained improvement or cure of the symptoms of overactive bladder due to development of a glycosaminoglycan layer. Long-term results are needed for confirmation.<br /> (Georg Thieme Verlag Stuttgart * New York.)
- Subjects :
- Administration, Intravesical
Administration, Oral
Adult
Aged
Cholinergic Antagonists administration & dosage
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Middle Aged
Prospective Studies
Quality of Life psychology
Tolterodine Tartrate
Urinary Bladder, Overactive psychology
Urodynamics drug effects
Benzhydryl Compounds administration & dosage
Chondroitin Sulfates administration & dosage
Cresols administration & dosage
Muscarinic Antagonists administration & dosage
Phenylpropanolamine administration & dosage
Urinary Bladder, Overactive drug therapy
Subjects
Details
- Language :
- German
- ISSN :
- 1438-8820
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Aktuelle Urologie
- Publication Type :
- Academic Journal
- Accession number :
- 19693752
- Full Text :
- https://doi.org/10.1055/s-0029-1224600