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Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity.
- Source :
-
Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2010 Apr; Vol. 20 (4), pp. 953-65. Date of Electronic Publication: 2009 Aug 14. - Publication Year :
- 2010
-
Abstract
- The cerebellum processes information from functionally diverse regions of the cerebral cortex. Cerebellar input and output nuclei have connections with prefrontal, parietal, and sensory cortex as well as motor and premotor cortex. However, the topography of the connections between the cerebellar and cerebral cortices remains largely unmapped, as it is relatively unamenable to anatomical methods. We used resting-state functional magnetic resonance imaging to define subregions within the cerebellar cortex based on their functional connectivity with the cerebral cortex. We mapped resting-state functional connectivity voxel-wise across the cerebellar cortex, for cerebral-cortical masks covering prefrontal, motor, somatosensory, posterior parietal, visual, and auditory cortices. We found that the cerebellum can be divided into at least 2 zones: 1) a primary sensorimotor zone (Lobules V, VI, and VIII), which contains overlapping functional connectivity maps for domain-specific motor, somatosensory, visual, and auditory cortices; and 2) a supramodal zone (Lobules VIIa, Crus I, and II), which contains overlapping functional connectivity maps for prefrontal and posterior-parietal cortex. The cortical connectivity of the supramodal zone was driven by regions of frontal and parietal cortex which are not directly involved in sensory or motor processing, including dorsolateral prefrontal cortex and the frontal pole, and the inferior parietal lobule.
- Subjects :
- Adult
Cerebral Cortex blood supply
Female
Functional Laterality physiology
Humans
Image Processing, Computer-Assisted methods
Magnetic Resonance Imaging methods
Male
Middle Aged
Neural Pathways blood supply
Neural Pathways physiology
Oxygen blood
Statistics as Topic
Brain Mapping
Cerebellum blood supply
Cerebellum physiology
Cerebral Cortex physiology
Mental Processes physiology
Rest physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2199
- Volume :
- 20
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cerebral cortex (New York, N.Y. : 1991)
- Publication Type :
- Academic Journal
- Accession number :
- 19684249
- Full Text :
- https://doi.org/10.1093/cercor/bhp157