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Proteomics meets blood banking: identification of protein targets for the improvement of platelet quality.
- Source :
-
Journal of proteomics [J Proteomics] 2010 Jan 03; Vol. 73 (3), pp. 436-44. Date of Electronic Publication: 2009 Aug 12. - Publication Year :
- 2010
-
Abstract
- Proteomics has brought new perspectives to the fields of hematology and transfusion medicine in the last decade. The steady improvement of proteomic technology is propelling novel discoveries of molecular mechanisms by studying protein expression, post-translational modifications and protein interactions. This review article focuses on the application of proteomics to the identification of molecular mechanisms leading to the deterioration of blood platelets during storage - a critical aspect in the provision of platelet transfusion products. Several proteomic approaches have been employed to analyse changes in the platelet protein profile during storage and the obtained data now need to be translated into platelet biochemistry in order to connect the results to platelet function. Targeted biochemical applications then allow the identification of points for intervention in signal transduction pathways. Once validated and placed in a transfusion context, these data will provide further understanding of the underlying molecular mechanisms leading to platelet storage lesion. Future aspects of proteomics in blood banking will aim to make use of protein markers identified for platelet storage lesion development to monitor proteome changes when alterations such as the use of additive solutions or pathogen reduction strategies are put in place in order to improve platelet quality for patients.<br /> ((c) 2009 Elsevier B.V. All rights reserved.)
- Subjects :
- Biomarkers analysis
Biomarkers metabolism
Blood Chemical Analysis methods
Blood Chemical Analysis trends
Blood Platelets metabolism
Blood Preservation adverse effects
Blood Preservation methods
Blood Preservation standards
Blood Proteins metabolism
Humans
Models, Biological
Quality Control
Biomarkers blood
Blood Banks trends
Blood Platelets cytology
Blood Proteins analysis
Proteomics methods
Blood Banking methods
Subjects
Details
- Language :
- English
- ISSN :
- 1876-7737
- Volume :
- 73
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of proteomics
- Publication Type :
- Academic Journal
- Accession number :
- 19683081
- Full Text :
- https://doi.org/10.1016/j.jprot.2009.08.002