Back to Search
Start Over
Motor cortex stimulation for ALS: a double blind placebo-controlled study.
- Source :
-
Neuroscience letters [Neurosci Lett] 2009 Oct 16; Vol. 464 (1), pp. 18-21. Date of Electronic Publication: 2009 Aug 12. - Publication Year :
- 2009
-
Abstract
- Preliminary data suggest that repetitive transcranial magnetic stimulation (rTMS) of the brain may produce a modest slowing of disease progression in amyotrophic lateral sclerosis (ALS). The present study was designed to test the hypothesis that rTMS given as continuous theta burst stimulation (cTBS), repeated monthly for one year, would affect ALS progression. We performed a double blind, placebo-controlled trial. Twenty patients with ALS were randomly allocated to blinded real or placebo stimulation. cTBS of the motor cortex was performed for five consecutive days every month for one year. Primary outcome was the rate of decline as evaluated with the revised ALS functional rating scale (ALSFRS-R). Treatment was well tolerated. There was no significant difference in the ALSFRS-R score deterioration between patients treated with real or placebo stimulation. ALSFRS-R mean scores declined from 32.0 (SD 7.1) at study entry to 23.1 (SD 6.3) at 12 months in patients receiving real cTBS and from 31.3 (SD 6.9) to 21.2 (SD 6.0) in those receiving placebo stimulation. Although cTBS proved a safe procedure, on the basis of the present findings a larger randomized confirmatory trial seems unjustified in ALS patients, at least in advanced stage of the disease.
- Subjects :
- Adult
Aged
Amyotrophic Lateral Sclerosis diagnosis
Amyotrophic Lateral Sclerosis physiopathology
Brain-Derived Neurotrophic Factor biosynthesis
Brain-Derived Neurotrophic Factor blood
Double-Blind Method
Female
Humans
Leukocytes, Mononuclear metabolism
Male
Middle Aged
Pilot Projects
Transcranial Magnetic Stimulation
Amyotrophic Lateral Sclerosis therapy
Motor Cortex physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 464
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 19682544
- Full Text :
- https://doi.org/10.1016/j.neulet.2009.08.020