Extrapyramidal symptoms and medication use in Mucopolysaccharidosis type III.

Authors :: Tchan MC
Sillence D
Source :: Journal of intellectual & developmental disability [J Intellect Dev Disabil] 2009 Sep; Vol. 34 (3), pp. 275-9.
Publication Year :: 2009
Abstract: Background: We report the case of a 16-year-old male with Mucopolysaccharidosis III type A (Sanfilippo syndrome) who was commenced on risperidone for behaviour management. He rapidly developed extrapyramidal symptoms that have not resolved.<br />Method: The medication histories of 20 patients with Mucopolysaccharidosis III seen at a Lysosomal Storage Diseases Clinic were reviewed to determine the incidence of extrapyramidal side effects.<br />Results: Six patients had been treated with risperidone, olanzapine, or lamotrigine. Five of these patients developed extrapyramidal side effects.<br />Conclusions: The incidence of extrapyramidal side effects was considerably higher than expected. We suggest that these medications be used with considerable caution in these patients.