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High rate of survival in transformed lymphoma after autologous stem cell transplant: pathologic analysis and comparison with de novo diffuse large B-cell lymphoma.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2009 Oct; Vol. 50 (10), pp. 1625-31. - Publication Year :
- 2009
-
Abstract
- Transformed lymphoma (TL) is historically associated with a poor prognosis, though autologous stem cell transplantation (ASCT) has been applied successfully. Better patient selection is needed for this intensive therapy. We analyzed the outcomes between de novo and transformed large B-cell lymphoma in patients undergoing ASCT, with regard to the immunohistochemical (IHC) features of potential prognostic utility including CD10, BCL6, MUM-1, Ki67, and BCL2. Of all patients undergoing ASCT for large B-cell lymphoma at the Cleveland Clinic Taussig Cancer Institute between 2003 and 2008, 56 patients (31 de novo and 25 TL) had undergone detailed IHC analysis. Three-year relapse-free-survival (RFS) and overall survival (OS) for TL vs. patients with de novo large B-cell lymphoma were 64%vs. 59% and 63%vs. 59%, respectively. More patients with TL were characterized as germinal-center B cell-of-origin (92%) than patients with de novo large B-cell lymphoma (71%). Immunohistochemistry did not predict relapse-free or overall survival, and ASCT afforded a high rate of PFS in patients with TL.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Cell Lineage
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Immunohistochemistry
Immunophenotyping
In Situ Hybridization, Fluorescence
Lymphoma, Large B-Cell, Diffuse drug therapy
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse surgery
Lymphoma, Non-Hodgkin drug therapy
Lymphoma, Non-Hodgkin pathology
Lymphoma, Non-Hodgkin surgery
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Survival Analysis
Survival Rate
Transplantation, Autologous
Lymphoma, Large B-Cell, Diffuse mortality
Lymphoma, Non-Hodgkin mortality
Peripheral Blood Stem Cell Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 50
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 19672775
- Full Text :
- https://doi.org/10.1080/10428190903128652