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The role of pro-inflammatory molecules and pharmacological agents in acute pancreatitis and sepsis.
- Source :
-
Inflammation & allergy drug targets [Inflamm Allergy Drug Targets] 2010 Mar; Vol. 9 (1), pp. 20-31. - Publication Year :
- 2010
-
Abstract
- Acute pancreatitis (AP) and sepsis are inflammatory disorder varying in magnitude of response to infection or inflammatory stimuli. The specific role of various causative factors in AP, septic shock, current pharmacological treatments, animal models, role of infiltrating cells and novel molecules that play an important role in the disease progression to sepsis are explored. AP is an inflammatory disease of the pancreas. Over the years accumulating evidence suggests numerous molecules as key regulators of the inflammatory signaling cascade such as selectins, chemokine signaling and expression of intergrins on leukocytes facilitate adhesion to vessel walls. Inhibition of any of these molecules has proven to be effective in animal models of AP. Recently, the biochemical role of hydrogen sulfide (H(2)S) and substance P in caerulein induced AP and in cecal ligation and puncture induced sepsis and their role in the pathogenesis of the disease have highlighted the importance of novel molecules as therapeutic targets in addition to the known pro-inflammatory molecules, cytokines and chemoattractant chemokines and their receptors upregulated in AP and sepsis. This review aims to give an overview of the multifaceted complex interactions in a prearranged fashion and their functional role in the inflammatory process that afflict AP and sepsis. The interlinking molecules in AP and sepsis emphasize the similarities in the inflammatory response and the importance of pharmacological agents that reduce or inhibit the progression to chronic stage.
- Subjects :
- Animals
Apoptosis
Ceruletide immunology
Chemokines immunology
Female
Humans
Hydrogen Sulfide toxicity
Integrins immunology
Male
Mice
Pancreatitis, Acute Necrotizing chemically induced
Pancreatitis, Acute Necrotizing pathology
Rats
Selectins immunology
Sepsis chemically induced
Sepsis pathology
Substance P immunology
Inflammation Mediators immunology
Pancreatitis, Acute Necrotizing immunology
Sepsis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2212-4055
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Inflammation & allergy drug targets
- Publication Type :
- Academic Journal
- Accession number :
- 19663805
- Full Text :
- https://doi.org/10.2174/187152810791292881