Back to Search
Start Over
Effects of a single-dose pretreatment with captopril on the immediate response to nasal challenge with allergen.
- Source :
-
International archives of allergy and applied immunology [Int Arch Allergy Appl Immunol] 1990; Vol. 93 (2-3), pp. 165-70. - Publication Year :
- 1990
-
Abstract
- We performed a double-blind, placebo-controlled, crossover study using 12 subjects to determine the effects of a single 50-mg dose of captopril on the response to nasal challenge with increasing doses of allergen. Levels of kinins, histamine and N-alpha-p-tosyl-L-arginine methyl ester (TAME)-esterase activity were measured in nasal lavages, and symptom scores and the number of sneezes were recorded. Captopril had no significant effects on histamine, TAME-esterase, sneezing or symptom scores. Peak postchallenge kinin levels, however, were significantly elevated (p less than 0.05) compared to placebo, while an increase in the magnitude of the dose-response curve was of marginal significance (p = 0.058). Thus, captopril causes increases in the kinin levels in nasal secretions during the allergic response. If increased kinin levels persist or worsen with chronic therapy, it is possible that they could exacerbate allergic symptoms during repeated seasonal exposure.
- Subjects :
- Adult
Captopril administration & dosage
Female
Histamine analysis
Humans
Male
Middle Aged
Nasal Mucosa metabolism
Peptide Hydrolases analysis
Peptidyl-Dipeptidase A physiology
Rhinitis, Allergic, Seasonal immunology
Captopril pharmacology
Kinins analysis
Nasal Mucosa drug effects
Rhinitis, Allergic, Seasonal metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0020-5915
- Volume :
- 93
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- International archives of allergy and applied immunology
- Publication Type :
- Academic Journal
- Accession number :
- 1965981
- Full Text :
- https://doi.org/10.1159/000235296